Article
Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake.
Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2010
Olson David P, Pulinilkunnil Thomas, Cline Gary W, Shulman Gerald I, Lowell Bradford B
Abstract excerpt
Deletion of acetyl CoA carboxylase-2 (Acc2) reportedly causes leanness in the setting of hyperphagia. To determine the cellular basis for these effects, we generated a mouse model in which Acc2 can be selectively deleted by the action of Cre recombinase. Deletion of Acc2 from skeletal muscle, the predominant site of Acc2 expression, had no effect on body weight, food intake, or body composition. When Acc2 was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.