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Article

Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal.

Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2005

Abu-Elheiga Lutfi, Matzuk Martin M, Kordari Parichher, Oh WonKeun, Shaikenov Tattym, Gu Ziwei, Wakil Salih J

Abstract excerpt

Acetyl-CoA carboxylases (ACC1 and ACC2) catalyze the carboxylation of acetyl-CoA to form malonyl-CoA, an intermediate metabolite that plays a pivotal role in the regulation of fatty acid metabolism. We previously reported that ACC2 null mice are viable, and that ACC2 plays an important role in the regulation of fatty acid oxidation through the inhibition of carnitine palmitoyltransferase I, a mitochondrial...

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Identifiers

PMID: 16103361
DOI: 10.1073/pnas.0505714102
PMCID: PMC1189351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal.PMID 16103361Read ↗

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.Semantic proximity Read ↗

Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice.Semantic proximity Read ↗

Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake.Semantic proximity Read ↗

Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype.Semantic proximity Read ↗

Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation.Semantic proximity Read ↗

Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and CancerSemantic proximity Read ↗

Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice.Semantic proximity Read ↗

Homozygous carnitine palmitoyltransferase 1a (liver isoform) deficiency is lethal in the mouseSemantic proximity Read ↗

Acetyl-CoA carboxylase regulates global histone acetylation.Semantic proximity Read ↗

Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development.Semantic proximity Read ↗

Acetyl-CoA carboxylase 1-dependent lipogenesis drives breast cancer progressionSemantic proximity Read ↗

Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions.Semantic proximity Read ↗

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