Extreme phenotype sampling and next generation sequencing to identify genetic variants associated with tacrolimus in African American kidney transplant recipients.

doi:10.1038/s41397-024-00349-8

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Article

Extreme phenotype sampling and next generation sequencing to identify genetic variants associated with tacrolimus in African American kidney transplant recipients.

The pharmacogenomics journal - 23 Aug 2024

Mohamed Moataz E, Guo Bin, Wu Baolin, Schladt David P, Muthusamy Amutha, Guan Weihua, Abrahante Juan E, Onyeaghala Guillaume, Saqr Abdelrahman, Pankratz Nathan, Agarwal Gaurav, Mannon Roslyn B, Matas Arthur J, Oetting William S, Remmel Rory P, Israni Ajay K, Jacobson Pamala A, Dorr Casey R

Abstract excerpt

African American (AA) kidney transplant recipients (KTRs) have poor outcomes, which may in-part be due to tacrolimus (TAC) sub-optimal immunosuppression. We previously determined the common genetic regulators of TAC pharmacokinetics in AAs which were CYP3A5 *3, *6, and *7. To identify low-frequency variants that impact TAC pharmacokinetics, we used extreme phenotype sampling and compared individuals with extreme...

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PMID: 39179559
DOI: 10.1038/s41397-024-00349-8

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CYP3A5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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