Article
Reduced white matter MRI transverse relaxation rate in cognitively normal H63D-HFE human carriers and H67D-HFE mice.
Brain imaging and behavior - 1 Dec 2016
Meadowcroft Mark D, Wang Jianli, Purnell Carson J, Peters Douglas G, Eslinger Paul J, Neely Elizabeth B, Gill David J, Vasavada Megha, Ali-Rahmani Fatima, Yang Qing X, Connor James R
Abstract excerpt
Mutations within the HFE protein gene sequence have been associated with increased risk of developing a number of neurodegenerative disorders. To this effect, an animal model has been created which incorporates the mouse homologue to the human H63D-HFE mutation: the H67D-HFE knock-in mouse. These mice exhibit alterations in iron management proteins, have increased neuronal oxidative stress, and a disruption in...
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