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Article

APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.

Molecular biology of the cell - 1 Feb 2016

Mills Kate M, Brocardo Mariana G, Henderson Beric R

Abstract excerpt

Mutations in adenomatous polyposis coli (APC) disrupt regulation of Wnt signaling, mitosis, and the cytoskeleton. We describe a new role for APC in the transport of mitochondria. Silencing of wild-type APC by small interfering RNA caused mitochondria to redistribute from the cell periphery to the perinuclear region. We identified novel APC interactions with the mitochondrial kinesin-motor complex Miro/Milton that...

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Source

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Identifiers

PMID: 26658612
DOI: 10.1091/mbc.E15-09-0632
PMCID: PMC4751598

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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