Identification of a link between the tumour suppressor APC and the kinesin superfamily.

doi:10.1038/ncb779

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Article

Identification of a link between the tumour suppressor APC and the kinesin superfamily.

Nature cell biology - 1 Apr 2002

Jimbo Takeshi, Kawasaki Yoshihiro, Koyama Ryo, Sato Rina, Takada Shinji, Haraguchi Keiko, Akiyama Tetsu

Abstract excerpt

The tumour suppressor gene adenomatous polyposis coli (APC) is mutated in sporadic and familial colorectal tumours. APC is involved in the proteasome-mediated degradation of beta-catenin, through its interaction with beta-catenin, GSK-3 beta and Axin. APC also interacts with the microtubule cytoskeleton and has been localized to clusters near the distal ends of microtubules at the edges of migrating epithelial...

Topics

Adenomatous Polyposis Coli Protein
Animals
Axin Protein
Brain
Calcium-Calmodulin-Dependent Protein Kinases
Cell Line
Cell Movement
Cytoskeletal Proteins
DNA, Complementary
Dogs
Epithelial Cells
Gene Library
Glycogen Synthase Kinase 3

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histones

Humans

Immunoblotting

Kinesins

Microscopy, Fluorescence

Source

Open in PubMed

Identifiers

PMID: 11912492
DOI: 10.1038/ncb779

Genes

Provenance

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