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Article

Identification of a link between the tumour suppressor APC and the kinesin superfamily.

Nature cell biology - 1 Apr 2002

Jimbo Takeshi, Kawasaki Yoshihiro, Koyama Ryo, Sato Rina, Takada Shinji, Haraguchi Keiko, Akiyama Tetsu

Abstract excerpt

The tumour suppressor gene adenomatous polyposis coli (APC) is mutated in sporadic and familial colorectal tumours. APC is involved in the proteasome-mediated degradation of beta-catenin, through its interaction with beta-catenin, GSK-3 beta and Axin. APC also interacts with the microtubule cytoskeleton and has been localized to clusters near the distal ends of microtubules at the edges of migrating epithelial...

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Source

Identifiers

PMID: 11912492
DOI: 10.1038/ncb779

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a link between the tumour suppressor APC and the kinesin superfamily.PMID 11912492Read ↗

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.Semantic proximity Read ↗

Novel self-association of the APC molecule affects APC clusters and cell migration.Semantic proximity Read ↗

Role of APC and its binding partners in regulating microtubules in mitosis.Semantic proximity Read ↗

APC shuttling to the membrane, nucleus and beyond.Semantic proximity Read ↗

Relationship between the role of the adenomatous polyposis coli protein in colon cancer and its contribution to cytoskeletal regulation.Semantic proximity Read ↗

The APC tumour suppressor has a nuclear export function.Semantic proximity Read ↗

Wnt signalling and the actin cytoskeleton.Semantic proximity Read ↗

Survivin-induced Aurora-B kinase activation: A mechanism by which APC mutations contribute to increased mitoses during colon cancer development.Semantic proximity Read ↗

Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization.Semantic proximity Read ↗

Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC.Semantic proximity Read ↗

APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.Semantic proximity Read ↗

Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation.Semantic proximity Read ↗

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