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Article

MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer.

The Journal of clinical investigation - 1 Jan 2016

Edmonds Mick D, Boyd Kelli L, Moyo Tamara, Mitra Ramkrishna, Duszynski Robert, Arrate Maria Pia, Chen Xi, Zhao Zhongming, Blackwell Timothy S, Andl Thomas, Eischen Christine M

Abstract excerpt

MicroRNA (miR) are important regulators of gene expression, and aberrant miR expression has been linked to oncogenesis; however, little is understood about their contribution to lung tumorigenesis. Here, we determined that miR-31 is overexpressed in human lung adenocarcinoma and this overexpression independently correlates with decreased patient survival. We developed a transgenic mouse model that allows for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26657862
DOI: 10.1172/JCI82720
PMCID: PMC4701567

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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