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Article

Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1.

Molecular cancer research : MCR - 1 Mar 2016

Kent Oliver A, Mendell Joshua T, Rottapel Robert

Abstract excerpt

UNLABELLED: Activating KRAS mutations are nearly ubiquitous in pancreatic cancer occurring in more than 95% of clinical cases. miRNAs are small noncoding RNAs that regulate gene expression by binding sequences within the 3'UTRs of target mRNAs. An integral role for miRNAs in cancer pathogenesis is well established; however, the role of miRNAs in KRAS-mediated tumorigenesis is poorly characterized. Here it is...

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Source

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Identifiers

PMID: 26747707
DOI: 10.1158/1541-7786.MCR-15-0456
PMCID: PMC4794362

Genes

KRAS
RASA1
ELK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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