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Article

Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1.

Molecular cancer research : MCR - 1 Mar 2016

Kent Oliver A, Mendell Joshua T, Rottapel Robert

Abstract excerpt

UNLABELLED: Activating KRAS mutations are nearly ubiquitous in pancreatic cancer occurring in more than 95% of clinical cases. miRNAs are small noncoding RNAs that regulate gene expression by binding sequences within the 3'UTRs of target mRNAs. An integral role for miRNAs in cancer pathogenesis i...

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Source

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Identifiers

PMID: 26747707
DOI: 10.1158/1541-7786.MCR-15-0456
PMCID: PMC4794362

Genes

KRAS
RASA1
ELK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-26747707-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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