Article

ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumor cell survival

2019-07-16

Abstract excerpt

Small cell lung cancer (SCLC) is the most aggressive form of lung cancer, and new molecular insights are necessary for prognostic and therapeutic advances. Here we demonstrate in orthotopic mouse models that dopamine and cAMP-regulated phosphoprotein, Mr 32000 (DARPP-32) and its N-terminally truncated splice variant t-DARPP promote SCLC growth through increased proliferation, Akt/Erk-mediated survival and anti-apo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 462dc749-6c04-59f1-861e-39a4151986b7
DOI: 10.1101/703975

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumor cell survivalDOI 10.1101/703975Read

DARPP-32 and t-DARPP promote lung cancer growth through IKKα-dependent cell migration and Akt/Erk-mediated cell survivalSemantic proximity Read

Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genesSemantic proximity Read

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic ProgramsSemantic proximity Read

PTEN Is a Potent Suppressor of Small Cell Lung CancerSemantic proximity Read

Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.Semantic proximity Read

ASCL1 represses a latent osteogenic program in small cell lung cancer in multiple cells of originSemantic proximity Read

Distinct Regulation of ASCL1 by the Cell Cycle and Chemotherapy in Small Cell Lung CancerSemantic proximity Read

DARPP-32 promotes ERBB3-mediated resistance to molecular targeted therapy in EGFR-mutated lung adenocarcinomaSemantic proximity Read

Autocrine loops, signal transduction, and cell cycle abnormalities in the molecular biology of lung cancerSemantic proximity Read

IKKα promotes lung adenocarcinoma growth through activation of ERK signaling via DARPP-32-mediated inhibition of PP1 activitySemantic proximity Read

Loss of p130 Accelerates Tumor Development in a Mouse Model for Human Small-Cell Lung CarcinomaSemantic proximity Read

Unravelling the genetic links between Parkinson's disease and lung cancer.Semantic proximity Read