Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LIN28B enhanced tumorigenesis in an autochthonous KRASG12V-driven lung carcinoma mouse model.

Oncogene - 1 May 2018

Meder Lydia, König Katharina, Dietlein Felix, Macheleidt Iris, Florin Alexandra, Ercanoglu Meryem S, Rommerscheidt-Fuss Ursula, Koker Mirjam, Schön Gisela, Odenthal Margarete, Klein Florian, Büttner Reinhard, Schulte Johannes H, Heukamp Lukas C, Ullrich Roland T

Abstract excerpt

LIN28B is a RNA-binding protein regulating predominantly let-7 microRNAs with essential functions in inflammation, wound healing, embryonic stem cells, and cancer. LIN28B expression is associated with tumor initiation, progression, resistance, and poor outcome in several solid cancers, including lung cancer. However, the functional role of LIN28B, especially in non-small cell lung adenocarcinomas, remains...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung
Share to Epithelial Cell Adhesion Molecule

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Hyaluronan Receptors

Share to Neoplasms, Experimental

Share to Proto-Oncogene Proteins p21(ras)

Share to RNA-Binding Proteins

Share to Survival Analysis

Source

Identifiers

PMID: 29503447
DOI: 10.1038/s41388-018-0158-7

Genes

KRAS
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LIN28B enhanced tumorigenesis in an autochthonous KRASG12V-driven lung carcinoma mouse model.PMID 29503447Read ↗

CUL4B functions as a tumor suppressor in KRAS-driven lung tumors by inhibiting the recruitment of myeloid-derived suppressor cells.Semantic proximity Read ↗

Dispensable role of CCL28 in Kras-mutated non-small cell lung cancer mouse models.Semantic proximity Read ↗

Lin28A Promotes the Amplification and Cancer Stemness of Lung Cancer Cells Via Activating MAPK Pathway Dependent on Let-7c FunctionsSemantic proximity Read ↗

Transcriptome Analysis of Individual Stromal Cell Populations Identifies Stroma-Tumor Crosstalk in Mouse Lung Cancer ModelSemantic proximity Read ↗

Syngeneic tobacco carcinogen-induced mouse lung adenocarcinoma model exhibits PD-L1 expression and high tumor mutational burden.Semantic proximity Read ↗

LIN28B: an orchestrator of oncogenic signaling in neuroblastoma.Semantic proximity Read ↗

Mouse models of human non-small-cell lung cancer: raising the bar.Semantic proximity Read ↗

MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer.Semantic proximity Read ↗

Modeling Molecular Pathogenesis of Idiopathic Pulmonary Fibrosis-Associated Lung Cancer in MiceSemantic proximity Read ↗

Identification of a Clinically Relevant Signature for Early Progression in KRAS-Driven Lung AdenocarcinomaSemantic proximity Read ↗

<i>miR-200</i> deficiency promotes lung cancer metastasis by activating cancer-associated fibroblastsSemantic proximity Read ↗

miR-494-3p is a novel tumor driver of lung carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.