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Article

NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression.

International journal of cancer - 1 Jan 2013

Okayama Hirokazu, Saito Motonobu, Oue Naohide, Weiss Jonathan M, Stauffer Jimmy, Takenoshita Seiichi, Wiltrout Robert H, Hussain S Perwez, Harris Curtis C

Abstract excerpt

Mutant KRAS in lung cancers induces molecular pathways that regulate cellular proliferation, survival and inflammation, which enhance tumorigenesis. Inducible nitric oxide synthase (NOS2) upregulation and sustained nitric oxide generation are induced during the inflammatory response and correlate positively with lung tumorigenesis. To explore the mechanistic contribution of NOS2 to KRAS-induced lung tumorigenesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22618808
DOI: 10.1002/ijc.27644
PMCID: PMC3473150

Genes

KRAS
NOS2
FOXP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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