Article
Age-related mutations and chronic myelomonocytic leukemia.
Leukemia - 1 Apr 2016
Mason C C, Khorashad J S, Tantravahi S K, Kelley T W, Zabriskie M S, Yan D, Pomicter A D, Reynolds K R, Eiring A M, Kronenberg Z, Sherman R L, Tyner J W, Dalley B K, Dao K-H, Yandell M, Druker B J, Gotlib J, O'Hare T, Deininger M W
Abstract excerpt
Chronic myelomonocytic leukemia (CMML) is a hematologic malignancy nearly confined to the elderly. Previous studies to determine incidence and prognostic significance of somatic mutations in CMML have relied on candidate gene sequencing, although an unbiased mutational search has not been conducted. As many of the genes commonly mutated in CMML were recently associated with age-related clonal hematopoiesis (ARCH)...
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