Aging and comprehensive molecular profiling in acute myeloid leukemia.

doi:10.1073/pnas.2319366121

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Article

Aging and comprehensive molecular profiling in acute myeloid leukemia.

Proceedings of the National Academy of Sciences of the United States of America - 5 Mar 2024

Li Jian-Feng, Cheng Wen-Yan, Lin Xiang-Jie, Wen Li-Jun, Wang Kai, Zhu Yong-Mei, Zhu Hong-Ming, Chen Xin-Jie, Zhang Yu-Liang, Yin Wei, Zhang Jia-Nan, Yi Xiao, Zhang Fan, Weng Xiang-Qin, Wang Sheng-Yue, Jiang Lu, Wu Hui-Yi, Ren Jia-Qi, Lin Xiao-Jing, Qiao Niu, Dai Yu-Ting, Fang Hai, Tan Yun, Sun Xiao-Jian, Lv Gang, Yan Xiao-Yu, Chen Su-Ning, Chen Zhu, Jin Jie, Wu De-Pei, Ren Rui-Bao, Chen Sai-Juan, Shen Yang

Abstract excerpt

Acute myeloid leukemia (AML) is an aging-related and heterogeneous hematopoietic malignancy. In this study, a total of 1,474 newly diagnosed AML patients with RNA sequencing data were enrolled, and targeted or whole exome sequencing data were obtained in 94% cases. The correlation of aging-related factors including age and clonal hematopoiesis (CH), gender, and genomic/transcriptomic profiles (gene fusions,...

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PMID: 38422020
DOI: 10.1073/pnas.2319366121
PMCID: PMC10927507

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