Article
Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged 75 years or older.
Haematologica - 1 Nov 2018
Prassek Victoria V, Rothenberg-Thurley Maja, Sauerland Maria C, Herold Tobias, Janke Hanna, Ksienzyk Bianka, Konstandin Nikola P, Goerlich Dennis, Krug Utz, Faldum Andreas, Berdel Wolfgang E, Wörmann Bernhard, Braess Jan, Schneider Stephanie, Subklewe Marion, Bohlander Stefan K, Hiddemann Wolfgang, Spiekermann Karsten, Metzeler Klaus H
Abstract excerpt
A cute myeloid leukemia is a disease of the elderly (median age at diagnosis, 65-70 years). The prognosis of older acute myeloid leukemia patients is generally poor. While genetic markers have become important tools for risk stratification and treatment selection in young and middle-aged patients, their applicability in very old patients is less clear. We sought to validate existing genetic risk classification...
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