Article
Defining Acute Myeloid Leukemia Ontogeny in Older Patients.
Clinical lymphoma, myeloma & leukemia - 1 May 2020
Melody Megan, Kuykendall Andrew, Sallman David, Al Ali Najla, Zhang Ling, Talati Chetasi, Padron Eric, Sweet Kendra, Extermann Martine, List Alan, Lancet Jeffrey, Komrokji Rami
Abstract excerpt
BACKGROUND: Acute myeloid leukemia (AML) in elderly patients is associated with poor outcomes and often arises from antecedent hematologic disorders (AHD), classified as secondary AML (sAML). PATIENTS AND METHODS: To validate the use of somatic mutations to determine AML ontogeny in the elderly population, we identified 178 elderly (> 70 years) patients with AML with NexGen Sequencing data. Patients were divided...
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