Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity.

Aging - 1 Dec 2015

Frankel Stewart, Woods Jared, Ziafazeli Tahereh, Rogina Blanka

Abstract excerpt

Single-gene mutations that extend longevity have revealed regulatory pathways related to aging and longevity. RPD3 is a conserved histone deacetylase (Class I HDAC). Previously we showed that Drosophila rpd3 mutations increase longevity. Here we tested the longevity effects of RPD3 on multiple nutrient levels. Dietary restriction (DR) has additive effects on RPD3-mediated longevity extension, but the effect may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Feed
Share to Drosophila melanogaster
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genotype

Share to Histone Deacetylase 1

Share to Longevity

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 26647291
DOI: 10.18632/aging.100856
PMCID: PMC4712336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity.PMID 26647291Read ↗

Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction.Semantic proximity Read ↗

Rpd3 interacts with insulin signaling in Drosophila longevity extension.Semantic proximity Read ↗

Heart-specific Rpd3 downregulation enhances cardiac function and longevity.Semantic proximity Read ↗

Royal jelly attenuates metabolic defects in a Drosophila mutant with elevated TORC1 activity.Semantic proximity Read ↗

A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageingSemantic proximity Read ↗

The conserved histone chaperone LIN-53 links lifespan and healthspan regulation in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

SIN3 is critical for stress resistance and modulates adult lifespanSemantic proximity Read ↗

Phenotypic characterization of SETD3 knockout Drosophila.Semantic proximity Read ↗

Comparative transcriptional profiling identifies takeout as a gene that regulates life spanSemantic proximity Read ↗

Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan.Semantic proximity Read ↗

MAP4K3 regulates body size and metabolism in Drosophila.Semantic proximity Read ↗

4E-BP functions as a metabolic brake used under stress conditions but not during normal growth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.