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Article

SIN3 is critical for stress resistance and modulates adult lifespan

7 Aug 2014

Abstract excerpt

Coordinate control of gene activity is critical for fitness and longevity of an organism. The SIN3 histone deacetylase (HDAC) complex functions as a transcriptional repressor of many genes. SIN3-regulated genes include those that encode proteins affecting multiple aspects of mitochondrial function, such as energy production and stress responsiveness, important for health maintenance. Here we used Drosophila...

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Share to Cholinesterase and Neurodegenerative Diseases
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Genomics, phytochemicals, and oxidative stress

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PMID: 25133314
DOI: 10.18632/aging.100684

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