Article
Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan.
Nature genetics - 1 Apr 2003
Ray Alo, Hector Ronald E, Roy Nilanjan, Song Jee-Hyeon, Berkner Kathleen L, Runge Kurt W
Abstract excerpt
An organism's lifespan is modulated by environmental conditions. When nutrients are abundant, the metabolism of many organisms shifts to growth or reproduction at the expense of longer lifespan, whereas a scarcity of nutrients reverses this shift. These correlations suggest that organisms respond to environmental changes by altering their metabolism to promote either reproduction and growth or long life. The only...
Topics
- Alleles
- Blotting, Western
- Fungal Proteins
- Gene Silencing
- MAP Kinase Signaling System
- Mitogen-Activated Protein Kinases
- Models, Biological
- Models, Genetic
- Molecular Sequence Data
- Mutation