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Article

MAP4K3 regulates body size and metabolism in Drosophila.

Developmental biology - 1 Aug 2010

Bryk Boris, Hahn Katrin, Cohen Stephen M, Teleman Aurelio A

Abstract excerpt

The TOR pathway mediates nutrient-responsive regulation of cell growth and metabolism in animals. TOR Complex 1 activity depends, amongst other things, on amino acid availability. MAP4K3 was recently implicated in amino-acid signaling in cell culture. We report here the physiological characterization of MAP4K3 mutant flies. Flies lacking MAP4K3 have reduced TORC1 activity detected by phosphorylation of S6K and...

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Identifiers

PMID: 20457147
DOI: 10.1016/j.ydbio.2010.04.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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