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Article

Rpd3 interacts with insulin signaling in Drosophila longevity extension.

Aging - 14 Nov 2016

Woods Jared K, Ziafazeli Tahereh, Rogina Blanka

Abstract excerpt

Histone deacetylase (HDAC) 1 regulates chromatin compaction and gene expression by removing acetyl groups from lysine residues within histones. HDAC1 affects a variety of processes including proliferation, development, metabolism, and cancer. Reduction or inhibition of Rpd3, yeast and fly HDAC1 orthologue, extends longevity. However, the mechanism of rpd3's effects on longevity remains unclear. Here we report an...

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Source

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Identifiers

PMID: 27852975
DOI: 10.18632/aging.101110
PMCID: PMC5191884

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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