Article
Variation in CYP2A6 and tobacco dependence throughout adolescence and in young adult smokers.
Drug and alcohol dependence - 1 Jan 2016
Chenoweth Meghan J, Sylvestre Marie-Pierre, Contreras Gisele, Novalen Maria, O'Loughlin Jennifer, Tyndale Rachel F
Abstract excerpt
BACKGROUND: Smoking is influenced by genetic factors including variation in CYP2A6 and CYP2B6, which encode nicotine-metabolizing enzymes. In early adolescence, CYP2A6 slow nicotine metabolism was associated with higher dependence acquisition, but reduced cigarette consumption. Here we extend this work by examining associations of CYP2A6 and CYP2B6 with tobacco dependence acquisition in a larger sample of smokers...
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