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Article

Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction.

Clinical pharmacology and therapeutics - 1 Apr 2008

Benowitz N L

Abstract excerpt

Understanding the basic and clinical pharmacology of nicotine provides a basis for improved prevention and treatment of tobacco addiction. Nicotine acts on nicotinic cholinergic receptors in the brain to release dopamine and other neurotransmitters that sustain addiction. Neuroadaptation and tolerance involve changes in both nicotinic receptors and neural plasticity. Nicotine addiction can occur in the context of...

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Identifiers

PMID: 18305452
DOI: 10.1038/clpt.2008.3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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