Article
CYP2A6 metabolism in the development of smoking behaviors in young adults.
Addiction biology - 1 Jan 2018
Olfson Emily, Bloom Joseph, Bertelsen Sarah, Budde John P, Breslau Naomi, Brooks Andrew, Culverhouse Robert, Chan Grace, Chen Li-Shiun, Chorlian David, Dick Danielle M, Edenberg Howard J, Hartz Sarah, Hatsukami Dorothy, Hesselbrock Victor M, Johnson Eric O, Kramer John R, Kuperman Samuel, Meyers Jacquelyn L, Nurnberger John, Porjesz Bernice, Saccone Nancy L, Schuckit Marc A, Stitzel Jerry, Tischfield Jay A, Rice John P, Goate Alison, Bierut Laura J
Abstract excerpt
Cytochrome P450 2A6 (CYP2A6) encodes the enzyme responsible for the majority of nicotine metabolism. Previous studies support that slow metabolizers smoke fewer cigarettes once nicotine dependent but provide conflicting results on the role of CYP2A6 in the development of dependence. By focusing on the critical period of young adulthood, this study examines the relationship of CYP2A6 variation and smoking...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.