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Article

CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers.

Pharmacogenetics and genomics - 1 Apr 2013

Chenoweth Meghan J, O'Loughlin Jennifer, Sylvestre Marie-Pierre, Tyndale Rachel F

Abstract excerpt

Variation in the CYP2A6 gene, which decreases the rate of nicotine metabolic inactivation, is associated with higher adult smoking cessation rates during clinical trials. We hypothesized that slow metabolism is associated with increased quitting during adolescence. White adolescent smokers (N=308, aged 12-17, 36.3% male) from a cohort study were genotyped for CYP2A6, resulting in 7.8% slow, 14.0% intermediate and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2A6

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Source

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Identifiers

PMID: 23462429
DOI: 10.1097/FPC.0b013e32835f834d
PMCID: PMC3744214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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