Article
CYP2A6 Longitudinal Effects in Young Smokers.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Feb 2016
Cannon Dale S, Medina Tait R, Mermelstein Robin J, Hedeker Donald, Bakian Amanda V, Coon Hilary, Cook Edwin H, Hamil Cindy, Weiss Robert B
Abstract excerpt
INTRODUCTION: The present study sought to identify time-dependent within-participant effects of CYP2A6 genotypes on smoking frequency and nicotine dependence in young smokers. METHODS: Predicted nicotine metabolic rate based on CYP2A6 diplotypes (CYP2A6 diplotype predicted rate [CDPR]) was partitioned into Normal, Intermediate, and Slow categories using a metabolism metric. Growth-curve models characterized...
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