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Article

Influence of CYP2A6 Genetic Variation, Nicotine Dependence Severity, and Treatment on Smoking Cessation Success.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 22 May 2023

Chenoweth Meghan J, Lerman Caryn, Knight Jo, Tyndale Rachel F

Abstract excerpt

INTRODUCTION: Genetic variation in Cytochrome P450 2A6 (CYP2A6), the major nicotine metabolizing enzyme, is associated with nicotine dependence and smoking cessation. Nicotine dependence severity also predicts smoking cessation. Our goals were to determine how CYP2A6 variation and nicotine dependence alter smoking cessation, and whether dependence could refine CYP2A6-based treatment recommendations. AIMS AND...

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Identifiers

PMID: 36789481
DOI: 10.1093/ntr/ntac268
PMCID: PMC10202625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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