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Article

Scrutinizing the FTO locus: compelling evidence for a complex, long-range regulatory context.

Human genetics - 1 Nov 2015

Rask-Andersen Mathias, Almén Markus Sällman, Schiöth Helgi B

Abstract excerpt

Single nucleotide polymorphisms (SNPs) within a genetic region including the first two introns of the gene encoding FTO have consistently been shown to be the strongest genetic factors influencing body mass index (BMI). However, this same also contains several regulatory DNA elements that affect the expression of IRX3 and IRX5, which respectively, are located approximately 500 kb and 1.2 Mbp downstream from the...

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Topics

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Share to Body Mass Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genetic Loci

Share to Homeodomain Proteins

Share to Obesity

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Share to Regulatory Elements, Transcriptional

Source

Identifiers

PMID: 26340902
DOI: 10.1007/s00439-015-1599-5

Genes

FTO
IRX3
IRX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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