Article
A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study.
PLoS genetics - 1 Jan 2013
Peters Ulrike, North Kari E, Sethupathy Praveen, Buyske Steve, Haessler Jeff, Jiao Shuo, Fesinmeyer Megan D, Jackson Rebecca D, Kuller Lew H, Rajkovic Aleksandar, Lim Unhee, Cheng Iona, Schumacher Fred, Wilkens Lynne, Li Rongling, Monda Keri, Ehret Georg, Nguyen Khanh-Dung H, Cooper Richard, Lewis Cora E, Leppert Mark, Irvin Marguerite R, Gu C Charles, Houston Denise, Buzkova Petra, Ritchie Marylyn, Matise Tara C, Le Marchand Loic, Hindorff Lucia A, Crawford Dana C, Haiman Christopher A, Kooperberg Charles
Abstract excerpt
Genetic variants in intron 1 of the fat mass- and obesity-associated (FTO) gene have been consistently associated with body mass index (BMI) in Europeans. However, follow-up studies in African Americans (AA) have shown no support for some of the most consistently BMI-associated FTO index single nucleotide polymorphisms (SNPs). This is most likely explained by different race-specific linkage disequilibrium (LD)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.