Article
An antibody tag-team: driving neutralization through escape.
Trends in immunology - 1 Sept 2014
Alter Galit, Ackerman Margaret E
Abstract excerpt
HIV rapidly mutates to escape antibody detection, and B cells counter this mutation by continual evolution to restore recognition, serendipitously resulting in the evolution of neutralizing activity in a fraction of infected individuals. A recent Cell paper describes how antibody repertoires stochastically collaborated, shaping the viral swarm and utilizing viral immune evasion to their advantage.
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