Article
Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly.
Molecular cell - 3 Mar 2016
Sugiyama Tomoyasu, Thillainadesan Gobi, Chalamcharla Venkata R, Meng Zhaojing, Balachandran Vanivilasini, Dhakshnamoorthy Jothy, Zhou Ming, Grewal Shiv I S
Abstract excerpt
Erh1, the fission yeast homolog of Enhancer of rudimentary, is implicated in meiotic mRNA elimination during vegetative growth, but its function is poorly understood. We show that Erh1 and the RNA-binding protein Mmi1 form a stoichiometric complex, called the Erh1-Mmi1 complex (EMC), to promote meiotic mRNA decay and facultative heterochromatin assembly. To perform these functions, EMC associates with two...
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