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Article

EGO-1, a putative RNA-dependent RNA polymerase, is required for heterochromatin assembly on unpaired dna during C. elegans meiosis.

Current biology : CB - 8 Nov 2005

Maine Eleanor M, Hauth Jessica, Ratliff Thomas, Vought Valarie E, She Xingyu, Kelly William G

Abstract excerpt

During meiosis in C. elegans, unpaired chromosomes and chromosomal regions accumulate high levels of histone H3 lysine 9 dimethylation (H3K9me2), a modification associated with facultative heterochromatin assembly and the resulting transcriptional silencing. Meiotic silencing of unpaired DNA may be a widely conserved genome defense mechanism. The mechanisms of meiotic silencing remain unclear, although both...

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Identifiers

PMID: 16271877
DOI: 10.1016/j.cub.2005.09.049
PMCID: PMC4098869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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