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Article

Heterochromatic breaks move to the nuclear periphery to continue recombinational repair.

Nature cell biology - 1 Nov 2015

Ryu Taehyun, Spatola Brett, Delabaere Laetitia, Bowlin Katherine, Hopp Hannah, Kunitake Ryan, Karpen Gary H, Chiolo Irene

Abstract excerpt

Heterochromatin mostly comprises repeated sequences prone to harmful ectopic recombination during double-strand break (DSB) repair. In Drosophila cells, 'safe' homologous recombination (HR) repair of heterochromatic breaks relies on a specialized pathway that relocalizes damaged sequences away from the heterochromatin domain before strand invasion. Here we show that heterochromatic DSBs move to the nuclear...

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Identifiers

PMID: 26502056
DOI: 10.1038/ncb3258
PMCID: PMC4628585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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