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Article

Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis

4 Sept 2017

Abstract excerpt

Intestinal regeneration and tumorigenesis are believed to be driven by intestinal stem cells (ISCs). Elucidating mechanisms underlying ISC activation during regeneration and tumorigenesis can help uncover the underlying principles of intestinal homeostasis and disease including colorectal cancer. Here we show that miR-31 drives ISC proliferation, and protects ISCs against apoptosis, both during homeostasis and...

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PMID: 28870287
DOI: 10.7554/elife.29538

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