Article

Enteroendocrine cells protect the stem cell niche by regulating crypt metabolism in response to nutrients

2022-10-02

Abstract excerpt

<h4>Background and aims</h4> The intestinal stem cell niche is exquisitely sensitive to changes in diet, with high fat diet, caloric restriction, and fasting resulting in altered crypt metabolism and intestinal stem cell function. Unlike cells on the villus, cells in the crypt are not immediately exposed to the dynamically changing contents of the lumen. We hypothesized that enteroendocrine cells (EECs), which se...

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Literature Corpus work: be182b2b-ef10-5499-ae91-7a9ddab37177
DOI: 10.1101/2022.10.01.508931

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