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Article

Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch.

Development (Cambridge, England) - 1 Jan 2015

López-Arribillaga Erika, Rodilla Verónica, Pellegrinet Luca, Guiu Jordi, Iglesias Mar, Roman Angel Carlos, Gutarra Susana, González Susana, Muñoz-Cánoves Pura, Fernández-Salguero Pedro, Radtke Freddy, Bigas Anna, Espinosa Lluís

Abstract excerpt

Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic goblet cells is unknown. To address this issue, we have generated composite tamoxifen-inducible intestine-specific genetic mouse models and...

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Source

Identifiers

PMID: 25480918
DOI: 10.1242/dev.107714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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