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Article

Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice

22 Sept 2021

Abstract excerpt

Excess nutrient uptake and altered hormone secretion in the gut contribute to a systemic energy imbalance, which causes obesity and an increased risk of type 2 diabetes and colorectal cancer. This functional maladaptation is thought to emerge at the level of the intestinal stem cells (ISCs). However, it is not clear how an obesogenic diet affects ISC identity and fate. Here we show that an obesogenic diet induces...

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PMID: 34552271
DOI: 10.1038/s42255-021-00458-9

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