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Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival

10 May 2022

Abstract excerpt

Autophagy defects are a risk factor for inflammatory bowel diseases (IBDs) through unknown mechanisms. Whole-body conditional deletion of autophagy-related gene (Atg) Atg7 in adult mice (Atg7Δ/Δ) causes tissue damage and death within 3 mo due to neurodegeneration without substantial effect on intestine. In contrast, we report here that whole-body conditional deletion of other essential Atg genes Atg5 or...

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PMID: 35537042
DOI: 10.1073/pnas.2202016119

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