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Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment

1 Apr 2019

Abstract excerpt

BACKGROUND: Glioblastoma (GBM), a highly malignant brain tumor, invariably recurs after therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is known about their molecular underpinnings. METHODS: Patient-derived GBM cells were engineered by CRISPR/Cas9-assisted knock-in of an inducible histone2B-GFP (iH2B-GFP) reporter to track cell division history. We utilized an in vitro 3D...

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PMID: 30952620
DOI: 10.1016/j.ebiom.2019.03.064

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