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Article

A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells

30 Oct 2012

Abstract excerpt

Glioblastoma growth is driven by cancer cells that have stem cell properties, but molecular determinants of their tumorigenic behavior are poorly defined. In cancer, altered activity of the epigenetic modifiers Polycomb and Trithorax complexes may contribute to the neoplastic phenotype. Here, we provide the first mechanistic insights into the role of the Trithorax protein mixed lineage leukemia (MLL) in...

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Share to Epigenetics and DNA Methylation
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PMID: 23108137
DOI: 10.1158/0008-5472.can-12-1881

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