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Article

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.

Nature medicine - 1 Jan 2016

Andor Noemi, Graham Trevor A, Jansen Marnix, Xia Li C, Aktipis C Athena, Petritsch Claudia, Ji Hanlee P, Maley Carlo C

Abstract excerpt

Intratumor heterogeneity (ITH) drives neoplastic progression and therapeutic resistance. We used the bioinformatics tools 'expanding ploidy and allele frequency on nested subpopulations' (EXPANDS) and PyClone to detect clones that are present at a ≥10% frequency in 1,165 exome sequences from tumors in The Cancer Genome Atlas. 86% of tumors across 12 cancer types had at least two clones. ITH in the morphology of...

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Identifiers

PMID: 26618723
DOI: 10.1038/nm.3984
PMCID: PMC4830693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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