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Article

Intra-Tumour Genetic Heterogeneity and Prognosis in High-Risk Neuroblastoma

15 Oct 2021

Abstract excerpt

Spatial ITH is defined by genomic and biological variations within a tumour acquired by tumour cell evolution under diverse microenvironments, and its role in NB patient prognosis is understudied. In this work, we applied pangenomic techniques to detect chromosomal aberrations in at least two different areas of each tumour and/or in simultaneously obtained solid and liquid biopsies, detecting ITH in the genomic...

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PMID: 34680323
DOI: 10.3390/cancers13205173

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