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Article

Tumour Cell Heterogeneity

29 Feb 2016

Abstract excerpt

The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, and discuss the ramifications and opportunities that ITH presents for cancer prognostication and treatment.

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PMID: 26973786
DOI: 10.12688/f1000research.7210.1

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