Article

Biophysical basis of cellular multi-specificity encoded in a model molecular switch

2020-01-06

Abstract excerpt

Molecular switches are central to signal transduction in protein interaction networks. One switch protein can independently regulate distinct cellular processes, but the molecular mechanisms enabling this functional multi-specificity remain unclear. Here we integrate system-scale cellular and biophysical measurements to study how a paradigm switch, the small GTPase Ran/Gsp1, achieves its functional multi-specifici...

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Literature Corpus work: bec25b15-e0f8-532a-9803-7a0765457803
DOI: 10.1101/2020.01.04.893909

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