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Article

Large enhancement of response times of a protein conformational switch by computational design.

Nature communications - 9 Mar 2018

DeGrave Alex J, Ha Jeung-Hoi, Loh Stewart N, Chong Lillian T

Abstract excerpt

The design of protein conformational switches-or proteins that change conformations in response to a signal such as ligand binding-has great potential for developing novel biosensors, diagnostic tools, and therapeutic agents. Among the defining properties of such switches, the response time has been the most challenging to optimize. Here we apply a computational design strategy in synergistic combination with...

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Identifiers

PMID: 29523842
DOI: 10.1038/s41467-018-03228-6
PMCID: PMC5844902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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