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Article

A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects.

Annals of human genetics - 1 Jan 2016

Li Ming, Li Jingyun, Wei Changshuai, Lu Qing, Tang Xinyu, Erickson Stephen W, MacLeod Stewart L, Hobbs Charlotte A

Abstract excerpt

Congenital heart defects (CHDs) develop through a complex interplay between genetic variants, epigenetic modifications, and maternal environmental exposures. Genetic studies of CHDs have commonly tested single genetic variants for association with CHDs. Less attention has been given to complex gene-by-gene and gene-by-environment interactions. In this study, we applied a recently developed likelihood-ratio...

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Source

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Identifiers

PMID: 26612412
DOI: 10.1111/ahg.12139
PMCID: PMC4839294

Genes

BHMT2
GPX3
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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