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Article

Maternal obesity and tobacco use modify the impact of genetic variants on the occurrence of conotruncal heart defects.

PloS one - 1 Jan 2014

Tang Xinyu, Nick Todd G, Cleves Mario A, Erickson Stephen W, Li Ming, Li Jingyun, MacLeod Stewart L, Hobbs Charlotte A

Abstract excerpt

Conotruncal heart defects (CTDs) are among the most severe birth defects worldwide. Studies of CTDs indicate both lifestyle behaviors and genetic variation contribute to the risk of CTDs. Based on a hybrid design using data from 616 case-parental and 1645 control-parental triads recruited for the National Birth Defects Prevention Study between 1997 and 2008, we investigated whether the occurrence of CTDs is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25275547
DOI: 10.1371/journal.pone.0108903
PMCID: PMC4183535

Genes

GCLC
GSTA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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