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Article

Paternal genetic variants and risk of obstructive heart defects: A parent-of-origin approach.

PLoS genetics - 1 Mar 2021

Patel Jenil, Bircan Emine, Tang Xinyu, Orloff Mohammed, Hobbs Charlotte A, Browne Marilyn L, Botto Lorenzo D, Finnell Richard H, Jenkins Mary M, Olshan Andrew, Romitti Paul A, Shaw Gary M, Werler Martha M, Li Jingyun, Nembhard Wendy N

Abstract excerpt

Previous research on risk factors for obstructive heart defects (OHDs) focused on maternal and infant genetic variants, prenatal environmental exposures, and their potential interaction effects. Less is known about the role of paternal genetic variants or environmental exposures and risk of OHDs. We examined parent-of-origin effects in transmission of alleles in the folate, homocysteine, or transsulfuration...

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Share to Alleles
Share to Cardiomyopathy, Hypertrophic, Familial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Mapping

Share to Heart Defects, Congenital

Share to Inheritance Patterns

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Identifiers

PMID: 33684136
DOI: 10.1371/journal.pgen.1009413
PMCID: PMC7971842

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