Article
Association of MTHFD1 gene polymorphisms and maternal smoking with risk of congenital heart disease: a hospital-based case-control study.
BMC pregnancy and childbirth - 31 Jan 2022
Song Xinli, Li Qiongxuan, Diao Jingyi, Li Jinqi, Li Yihuan, Zhang Senmao, Zhao Lijuan, Chen Letao, Wei Jianhui, Shu Jing, Liu Yiping, Sun Mengting, Huang Peng, Wang Tingting, Qin Jiabi
Abstract excerpt
BACKGROUND: MTHFD1 gene may affect the embryonic development by elevated homocysteine levels, DNA synthesis and DNA methylation, but limited number of genetic variants of MTHFD1 gene was focused on the association with congenital heart disease (CHD). This study examined the role of MTHFD1 gene and maternal smoking on infant CHD risk, and investigated their interaction effects in Chinese populations. METHODS: A...
Topics
- Adult
- Asian People
- Case-Control Studies
- China
- Female
- Heart Defects, Congenital
- Humans
- Infant, Newborn
- Infant, Newborn, Diseases
- Logistic Models