Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association analysis of maternal MTHFR gene polymorphisms and the occurrence of congenital heart disease in offspring.

BMC cardiovascular disorders - 14 Jun 2021

Sun Mengting, Wang Tingting, Huang Peng, Diao Jingyi, Zhang Senmao, Li Jinqi, Luo Liu, Li Yihuan, Chen Letao, Liu Yiping, Wei Jianhui, Song Xinli, Sheng Xiaoqi, Qin Jiabi

Abstract excerpt

BACKGROUND: Although many studies showed that the risk of congenital heart disease (CHD) was closely related to genetic factors, the exact pathogenesis is still unknown. Our study aimed to comprehensively assess the association of single nucleotide polymorphisms (SNPs) of maternal MTHFR gene with risk of CHD and its three subtypes in offspring. METHODS: A case-control study involving 569 mothers of CHD cases and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Association Studies
Share to Heart Defects, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterozygote

Share to Homozygote

Share to Linkage Disequilibrium

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Pregnancy

Share to Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 34126931
DOI: 10.1186/s12872-021-02117-z
PMCID: PMC8204503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association analysis of maternal MTHFR gene polymorphisms and the occurrence of congenital heart disease in offspring.PMID 34126931Read ↗

Association between maternal MTHFR and MTRR gene polymorphisms and the risk of congenital heart disease in newbornsSemantic proximity Read ↗

Maternal MTHFR A1298C polymorphism and risk of congenital heart disease in fetusSemantic proximity Read ↗

Association of MTHFD1 gene polymorphisms and maternal smoking with risk of congenital heart disease: a hospital-based case-control study.Semantic proximity Read ↗

Association Between MTHFR C677T Polymorphism and Congenital Heart Disease.Semantic proximity Read ↗

Study on Maternal SNPs of MTHFR Gene and HCY Level Related to Congenital Heart Diseases.Semantic proximity Read ↗

Study on Environmental Causes and SNPs of MTHFR, MS and CBS Genes Related to Congenital Heart Disease.Semantic proximity Read ↗

Association between maternal MTHFR and MTRR gene polymorphisms and the risk of congenital heart disease in newborns.Semantic proximity Read ↗

Association of MTHFD Gene Polymorphisms and Maternal Smoking With Risk of Congenital Heart Disease: A Hospital-Based Case-Control StudySemantic proximity Read ↗

[Association of maternal MTHFD1 and MTHFD2 gene polymorphisms with congenital heart disease in offspring].Semantic proximity Read ↗

Association between MTHFR polymorphisms and congenital heart disease: a meta-analysis based on 9,329 cases and 15,076 controls.Semantic proximity Read ↗

Association analysis between MTHFR genetic polymorphisms and the risk of congenital heart diseases in Chinese Han population.Semantic proximity Read ↗

The association between c.1333C > T genetic polymorphism of MTHFR gene and the risk of congenital heart diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.