Article
Ancestry-based differences in the immune phenotype are associated with lupus activity.
JCI insight - 22 Aug 2023
Slight-Webb Samantha, Thomas Kevin, Smith Miles, Wagner Catriona A, Macwana Susan, Bylinska Aleksandra, Donato Michele, Dvorak Mai, Chang Sarah E, Kuo Alex, Cheung Peggie, Kalesinskas Laurynas, Ganesan Ananthakrishnan, Dermadi Denis, Guthridge Carla J, DeJager Wade, Wright Christian, Foecke Mariko H, Merrill Joan T, Chakravarty Eliza, Arriens Cristina, Maecker Holden T, Khatri Purvesh, Utz Paul J, James Judith A, Guthridge Joel M
Abstract excerpt
Systemic lupus erythematosus (SLE) affects 1 in 537 Black women, which is >2-fold more than White women. Black patients develop the disease at a younger age, have more severe symptoms, and have a greater chance of early mortality. We used a multiomics approach to uncover ancestry-associated immune alterations in patients with SLE and healthy controls that may contribute biologically to disease disparities. Cell...
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